Last edited by Kagul
Tuesday, August 4, 2020 | History

2 edition of effect of an immunosuppressive agent on the pertussis mouse protection test. found in the catalog.

effect of an immunosuppressive agent on the pertussis mouse protection test.

Helen Elizabeth Blake

effect of an immunosuppressive agent on the pertussis mouse protection test.

by Helen Elizabeth Blake

  • 304 Want to read
  • 7 Currently reading

Published in [Toronto] .
Written in English

    Subjects:
  • Immunology,
  • Whooping cough -- Immunological aspects,
  • Vaccines -- Testing

  • Edition Notes

    ContributionsToronto, Ont. University. Theses (M.Sc.)
    Classifications
    LC ClassificationsLE3 T525 MSC 1968 B52
    The Physical Object
    Pagination[72 leaves]
    Number of Pages72
    ID Numbers
    Open LibraryOL17430158M

    In , Cooperstock found that endotoxin could be inactivated by polymyxin B. Studies by Bannatyne et al [, ] found that exposure of DTwP vaccines to polymyxin B decreased endotoxin activity, as assessed in a limulus-lysate test. This treatment did not decrease the protective effect of the vaccine in a mouse-protection test.   Since successful treatment of superficial bladder cancer with BCG requires proper induction of Th1 immunity, we have developed a rBCG-S1PT strain that induced a stronger cellular immune response than BCG. This preclinical study was designed to compare the modulatory effects of BCG and rBCG-S1PT on bladder TNF-α and IL expression and to evaluate antitumour activity.

    All selective immunosuppressant agents reduce immune function to some degree and increase the risk for the person to develop an infection. None of the other agents listed have this side effect. and pertussis given to older children and adults who have already received the DTaP series. DTaP is the vaccination given in infancy and early. Selective immunosuppressive agents are drugs that suppress the immune system due to a selective point of action. They are used to reduce the risk of rejection in organ transplants, in autoimmune diseases and can be use as cancer chemotherapy. As immunosuppressive agents lower the immunity there is increased risk of infection.

      Immunosuppressant drugs are a class of drugs that suppress, or reduce, the strength of the body’s immune system. Some of these drugs are used to make the body less likely to reject a. For agents not considered highly immunosuppressive, consultation with the prescribing clinician (and possibly a hospital pharmacist) is recommended to manage individual patients and estimate degree of immunosuppression. No basis exists for interpreting laboratory studies of general immune parameters to predict vaccine safety or efficacy.


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Effect of an immunosuppressive agent on the pertussis mouse protection test by Helen Elizabeth Blake Download PDF EPUB FB2

Can J Microbiol. Dec;15(12) Intracerebral mouse protection test for petussis vaccine. Immunosuppression with by: 2.

The effect of the antigen which elicits the bactericidal antibody and of the mouse-protective antiǵen on the growth of Bordetella Intracerobral mouse protection test for pertussis vaccine.

Immunosuppression with cyclophosphamide. Canadian Journal of Microbiol Intracerebral mouse protection test for pertussis vaccino. by: 3. Bordetella pertussis, the causative agent of pertussis Indeed, these immunosuppressive effects of PT can leave mice will provide better protection against B.

pertussis than a Cited by: Passive immunization has been used to investigate the hypothesis that the immunity mechanism in the standard intracerebral mouse protection test for pertussis vaccine depends on the movement of humoral protective antibody across the blood–brain barrier on the fourth or fifth day after by: 4.

Gadeberg, O. V., Rhodes, J. M., and Larsen, S. () The effect of various immunosuppressive agents on mouse peritoneal macrophages and on the in vitro phagocytosis of Escherichia coli O4:K3:H5 and degradation of I-labelled HSA-antibody complexes by these cells.

Immunol 59– PubMed Google Scholar. Bordetella pertussis is the agent of pertussis, also referred to as whooping cough, a disease that remains an important public health issue. Vaccine-induced immunity to pertussis wanes over time.

In industrialized countries, high vaccine coverage has not prevented infection and transmission of B. pertussis, leading to periodic outbreaks in people of all ages.

THE INTRACEREBRAL MOUSE-PROTECTION TEST FOR PERTUSSIS VACCINES BY J. IRWIN Statistical Research Unit of the Medical Research Council, London School of Hygiene and Tropical Medicine, Keppel Street, W.C.I AND A.

STANDFAST The Lister Institute of Preventive Medicine, Elstree, Hertfordshire CONTENTS PAGE. Abstract. It was tempting to call this survey ‘immunosuppression by non-immunosuppressive agents’. The term immunosuppressive agent or immunosuppressant applies to a group of compounds with cytotoxic and antiproliferative properties belonging to such classes as alkylating agents.

A.M. Harandi, N. Lycke, in Immunopotentiators in Modern Vaccines (Second Edition), Pertussis Toxin–Derived Adjuvants. PT is produced by Bordetella pertussis, the causative agent of whooping also shares the AB 5 structure with CT and LT and is transported to the cytosol via retrograde transport in an analogous fashion to the other toxins.

However, in contrast to CT and. 1. Introduction. Natural and synthetic glucocorticoids remain at the forefront of anti-inflammatory and immunosuppressive therapies. They are widely used to treat both acute and chronic inflammations, including rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, psoriasis and eczema, as well as being used in treatment of certain leukaemias and in immunosuppressive.

Pertussis vaccine is a suspension of inactivated B. pertussis cells. Potency is assayed by comparison with the U.S. standard pertussis vaccine in the intracerebral mouse protection test. The protective efficacy of pertussis vaccines for humans has been shown to. cancer, and a myriad of other side effects.

Further, they fail to prevent and control chronic rejection. This review will outline a number of immunosuppressive agents that are currently being explored in experimental and clinical transplantation. These include biologic agents that. Immunosuppression is the mainstay of therapy for PCRA.

Corticosteroids are the traditional first line but ciclosporin is at least as effective in achieving remission and has fewer side-effects. Withdrawal of putative agents, drugs or erythropoietin, is essential.

Treatment is effective for almost all etiologies except severe post stem. potential replacement for the intracerebral mouse protection test for potency assay of pertussis whole-cell vaccines. Dev. Biol. Stand. () 2. Corbel MJ, Xing DK: Toxicity and potency evaluation of pertussis vaccines.

es () 3. Decker MD, Edwards KM (Eds) Report of the Nationwide Multicenter Acellular. Pertussis is a severe respiratory infection caused by Bordetella pertussis, and inpertussis was associated with an estimated 16 million cases anddeaths globally.

Sizeable outbreaks of pertussis have been reported over the past 5 years, and disease reemergence has been the focus of international attention to develop a deeper understanding of pathogen virulence and genetic.

To test our hypothesis, infant baboons were vaccinated at 2, 4, and 6 mo of age with aP or whole-cell pertussis (wP) vaccines and challenged with B. pertussis at 7 mo. Infection was followed by. It was also shown that vaccines with acceptable mouse protection potencies induced protective serum agglutinin antibody titers.

4 The pertussis component of each lot of DTP (diphtheria and tetanus toxoids and pertussis vaccine adsorbed usp) is tested for potency by a mouse protection test.

Pertussis toxin (PT), a secreted virulence factor of Bordetella pertussis, ADP ribosylates mammalian Gi proteins and plays an important early role in respiratory tract infection by this pathogen in a mouse intranasal infection model.

To test the hypothesis that PT targets resident airway macrophages (AM) to promote this infection, we depleted AM by intranasal administration of liposome.

Type 1 strains of Bordetella pertussis can infect mouse brain and have been recovered as type 1 organisms after death. When introduced into the nasopharynx of the marmoset, they immediately acquired agglutinogen 2 or 3, and the resulting type 1, 2 or 1, 3 infection persisted for many weeks.

" As in the child, agglutinogens 2 and/or 3 appear to be essential for infection of the marmoset, whereas. Pertussis—The potency of the inactivated B. pertussis cells in the vaccine is assayed by comparison with the U.S.

standard pertussis vaccine in the intracerebral mouse protection test. The protective efficacy of pertussis vaccines for humans has been shown to correlate with the measure of vaccine potency. {01} {05}. Previously, a B.

pertussis strain lacking functional PT was shown to induce higher antibody levels in mice than wild-type strains, indicating that our findings are associated with the attenuation of an immunosuppressive effect of PT.

Defining correlates of protection against B. pertussis has been notoriously difficult. However, priming.Stability of H. pertussis Vaccine Estimated by Mouse-protection Test; Articles Stability of H. pertussis Vaccine Estimated by Mouse-protection Test Br Med J ; Stability of H. pertussis Vaccine Estimated by Mouse-protection Test Br Med J ; BibTeX (win & mac)Download; EndNote (tagged)Download; EndNote 8 (xml)Download.Pertussis toxin (PT), a virulence factor secreted by Bordetella pertussis, contributes to respiratory tract infection and disease caused by this pathogen.

By comparing a wild-type (WT) B. pertussis strain to a mutant strain with an in-frame deletion of the ptx genes encoding PT (ΔPT), we recently found that the lack of PT confers a significant defect in respiratory tract colonization in mice.